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Développement d'un modèle cellulaire de la DMLA à partir de cellules de patients pour étudier la physiopathologie de la maladie

Abstract : First cause of irreversible visual dysfunction in industrialized countries, age-related macular degeneration (AMD) is a retinal disease affecting people after 55 years old. AMD is characterized by the macular degeneration of retina and by formation of drusen. There exist two forms of the disease: the exudative and the atrophic forms. In our study, we focused only on the atrophic one, corresponding to approximately 50% of the clinical cases in Europe, that still today without curative therapy. Despite many researches, AMD's etiology remains unclear even if environmental and genetics factors would be involved. According to the etiopatogenic hypothesis, RPE cells dysfunction has a central role in the physiopathological events leading to AMD. From healthy subjects and patients affected by atrophic AMD, we obtained RPE cells derived from induced pluripotent stem cells and developed a useful human cellular model for the understanding of AMD mechanisms. Indeed, the morphological and functional study of the two types of cells populations underlined a particular phenotype for the RPE cells derived from AMD patients. This cellular model will allow us to have a better understanding of mechanisms leading to AMD and will also be used to screen therapeutic molecules before clinical studies.
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https://hal-univ-poitiers.archives-ouvertes.fr/tel-02498161
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Audrey Voisin. Développement d'un modèle cellulaire de la DMLA à partir de cellules de patients pour étudier la physiopathologie de la maladie. Organes des sens. Université de Poitiers, 2017. Français. ⟨tel-02498161⟩

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