A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors

Marion Gay (1) , Caroline Evrard (1) , Florian Descamps (1) , Pascal Carato (1, 2) , Nicolas Renault (3) , Mathilde Coevoet (1) , Sabiha Eddarkaoui (1) , Catherine Baud (1) , Paul-Emmanuel Larchanché (1) , Luc Buée (1) , Jamal El Bakali (1) , Valérie Vingtdeux (1) , Nicolas Sergeant (1) , Patricia Melnyk (1)

1 U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog
2 Inserm CIC-P 1402, department of gynecology-obstetric and reproductive medicine, CHU Poitiers, Poitiers, France
3 LIRIC - Lille Inflammation Research International Center - U 995

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Domains: Chemical Sciences

Marion Gay, Caroline Evrard, Florian Descamps, Pascal Carato, Nicolas Renault, et al.. A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors. European Journal of Medicinal Chemistry, 2018, 159, pp.104-125. ⟨10.1016/j.ejmech.2018.08.092⟩. ⟨hal-04035729⟩